BPC-157
Body Protection Compound — 157
Synthetic pentadecapeptide fragment derived from a gastric protein sequence.
BPC-157 is a 15-amino-acid synthetic peptide originally identified as a fragment of a protein found in gastric juice. It is widely used in preclinical studies investigating tissue-repair signalling pathways, vascular remodelling, and gastrointestinal physiology.
The sequence is unusually proline-rich (4 of 15 residues), giving the chain a constrained backbone that resists enzymatic degradation in acidic conditions. The N-terminus carries a free glycine; the C-terminus ends in valine.
- + Studied in animal models of soft-tissue and mucosal injury.
- + Frequently paired with TB-500 in regenerative research literature.
- − No approved clinical use. Not a drug. Not for diagnosis or treatment.
- − No dosing, reconstitution, or administration guidance provided.
Pathways under study
eNOS pathway modulation has been described in vascular and gastric tissue preparations.
Receptor expression and angiogenic markers studied in injury-site models.
Reports of altered FGF, EGF, and collagen-related gene expression in repair models.
Where it appears in the literature
Rodent Achilles and quadriceps transection models — collagen organisation, fibroblast outgrowth.
Crush and strain models — angiogenic markers, regeneration timeline.
Gastric and esophageal lesion models — original context of the parent protein.
Endothelial NO synthase pathway studies; VEGFR-2 expression in injury sites.
Neural-regeneration literature exploring dopaminergic and serotonergic systems.
Skin wound and cartilage models, granulation tissue formation.
Lyophilized powder is stable long-term at −20 °C, light-protected, in original sealed vial.
Ships ambient. Lyophilized form tolerates short transit windows without cold chain.
Every lot is HPLC-tested to ≥99% purity with mass spectrometry confirmation and lot tracking.
References
Provided for research context only. Inclusion does not imply any claim about the product or its use.
- Pentadecapeptide BPC 157 and the central nervous systemSikiric et al., Neural Regen Res, 2022
- BPC 157 — A novel cytoprotective peptide with potential therapeutic applicationsSeiwerth et al., Curr Pharm Des, 2018
- Stable gastric pentadecapeptide BPC 157 and tendon-to-bone healingKrivic et al., J Orthop Res, 2006
- BPC 157 enhances the healing of transected rat Achilles tendonStaresinic et al., J Orthop Res, 2003
- BPC 157 and nitric-oxide system in cardiovascular researchVukojević et al., Inflammopharmacology, 2018