Adamax
Proprietary nasal vehicle featuring our Enhanced Delivery Mechanism.
Adamax is supplied in our proprietary nasal vehicle built around a cyclodextrin-based inclusion-complex system. The vehicle was designed specifically to solubilise the lipophilic adamantyl portion of the active and to maintain stability in an aqueous, nasal-tolerable medium.
The active is complexed with HP-β-cyclodextrin, with chitosan as a mucoadhesive and absorption enhancer, HPMC as a viscosity modifier, in an isotonic buffered base at pH 5.5–6.5. See the Enhanced Delivery Mechanism section below for full vehicle composition.
Adamax Nasal Vehicle
Cyclodextrins are cyclic oligosaccharides used as pharmaceutical excipients to improve drug solubility, stability, and bioavailability. They feature a hydrophilic outer surface and a lipophilic inner cavity, allowing them to form inclusion complexes that act as molecular shields for drug molecules. The Adamax vehicle was engineered around this principle.
A cyclodextrin — a cyclic oligosaccharide carrier molecule. It forms an inclusion complex with the lipophilic adamantyl portion, acting as a molecular shield that improves aqueous solubility and stability.
A natural cationic polysaccharide that helps the formulation remain in contact with the nasal mucosa and improves permeation across the mucosal layer.
Hydroxypropyl methylcellulose — a mild mucoadhesive that supports even distribution and keeps the formulation from running off.
An aqueous base matched to physiological salt concentration so the formulation is nasal-tolerable.
Tuned to the natural nasal pH range for tolerability and chemical stability of the active.
Helps disperse the active uniformly throughout the vehicle.
Protects the formulation from oxidative and trace-metal degradation over its shelf life.
USP-grade sterile water as the bulk solvent.
Single-use format avoids preservatives entirely; multidose formats use nasal-tolerable preservation only.
Selected references
Provided for research context only. Inclusion does not imply any claim about the product or its use.
- Cyclodextrins as pharmaceutical excipients — A reviewLoftsson & Brewster, J Pharm Sci, 1996
- Chitosan as a nasal absorption enhancerIllum et al., Pharm Res, 1994